The Morning Dispatch: Is a COVID Booster in Your Future?

Happy Wednesday! The mainstream media may have declared the Brookings Institution the winner of last nightโ€™s softball game, but weโ€™re going to hold off on jumping to any conclusions until any and all legal challenges play out in court.ย 

(We lost by one run after a discrepancy emerged in the two teamsโ€™ scorebooks. Canโ€™t wait for the rematch in the playoffs.)

Quick Hits: Todayโ€™s Top Stories

  • Mass unrest has swept through South Africa in recent days in response to the jailing of the nationโ€™s former president, Jacob Zuma. Police in the country say the rioting and looting has led to more than 70 deaths and 1,200 arrests. South Africaโ€™s Constitutional Court sentenced Zuma to 15 months in prison last month for contempt of court after he refused to appear before a government-appointed commission looking into corruption that allegedly took place during his presidency.

  • The Bureau of Labor Statistics reported yesterday that the Consumer Price Index (CPI) jumped 0.9 percent in June, the largest month-over-month increase in the inflationary measure in 13 years. On an annual basis, CPI is up 5.4 percent.

  • U.S. Central Command announced Tuesday that it estimates the American withdrawal from Afghanistan to be more than 95 percent complete.

  • The Department of Justice announced Tuesday that four Iranian intelligence officials had been indicted on federal charges for conspiring to kidnap a U.S. citizenโ€”a Brooklyn journalist originally from Iran who has been critical of the regimeโ€”โ€œand to forcibly take their intended victim to Iran, where the victimโ€™s fate would have been uncertain at best.โ€

  • In a supply chain business advisory issued yesterday by the State Department, Treasury Department, and four other federal agencies, the government warned that businesses operating in Xinjiang โ€œcould run a high risk of violating U.S. lawโ€ due to the extent of human rights abuses in the region. The advisory urged businesses involved in assisting or developing Chinese surveillance tools, sourcing labor or goods from Xinjiang, supplying U.S. products to entities using forced labor or surveillance, or constructing internment facilities to exercise heightened due diligence to ensure they are not violating U.S. or international law.

  • The websites associated with Russian hacking group REvilโ€”the organization behind the July 2 ransomware attack on Kaseyaโ€”went offline Tuesday, putting an abrupt halt to ransom payment negotiations. Neither the Biden administration nor Russian President Vladimir Putin have taken credit for the development, but the disappearance came just days after President Biden called Putin and, according to a White House readout, threatened to โ€œtake any necessary actionโ€ to stop the attacks.

  • Democrats on the Senate Budget Committee announced last night that they had come to an agreement on a $3.5 trillion โ€œhuman infrastructureโ€ package that they plan to try to pass through the budget reconciliation process, which requires only 50 votes. Itโ€™s unclear, however, if all 50 Senate Democrats are on board with that large a figure.

Will Two Vaccine Doses Be Enough?

(Stock photo via Getty Images.)

Israel is now offering a third dose of the COVID-19 vaccine to immunocompromised adults, and the United Kingdom is preparing for a similar move later this year. In the United States, Pfizer is seeking an emergency use authorization (EUA) for a third dose of its vaccine, and top public health officials held a closed-door meeting with representatives from the company on Monday. As the Delta variant continues to spread, will booster shots become necessary?

For now, the answer is no. Just hours after Pfizer announced it was seeking an expanded EUA, the Centers for Disease Control (CDC) and the Food and Drug Administration (FDA) issued a rare joint statement. โ€œAmericans who have been fully vaccinated do not need a booster shot at this time,โ€ it read. โ€œWe continue to review any new data as it becomes available and will keep the public informed. We are prepared for booster doses if and when the science demonstrates that they are needed.โ€

Scientists and physicians have generally echoed this sentiment. โ€œWhen do you cross a line where you can say that you need to boost immunity?โ€ said Dr. Paul Offit, director of the vaccine education program at Childrenโ€™s Hospital of Philadelphia. โ€œI think that line gets crossed when a critical percentage of people who, despite being fully vaccinated, are either hospitalized or killed by this virus. Right now, that percentage is less than 1 percent, so you donโ€™t need a booster.โ€

โ€œI think itโ€™s very unlikely that the ACIP, the Advisory Committee on Immunization Practices, will issue any recommendations in the near term concerning the need for boosters for the general population,โ€ added Dr. William Schaffner, an infectious disease specialist at the Vanderbilt University Medical Center who is currently a non-voting liaison to the ACIP. โ€œNow, that said, there might be some consideration for people whose immune systems are impaired.โ€

While Pfizer would obviously benefit financially from selling additional vaccine dosesโ€”to Americans, or, more likely, the federal governmentโ€”the pharmaceutical companyโ€™s movements in recent weeks have almost assuredly been backed by data.ย 

โ€œ[Pfizer] already must know that antibodies are waning, or else they wouldnโ€™t have been making these bold statements right now,โ€ Howard Forman, a public health policy expert at Yale University, told The Dispatch. But that on its own likely wonโ€™t be enough to convince FDA and CDC regulators a third dose is necessary; the immune systemโ€™s response to COVID-19 is based on more than antibodies alone.ย 

โ€œEven if we saw waning antibodies, it is still possible that you would have very strong protection from T-cell immunity,โ€ Forman said. โ€œWe just donโ€™t know; people havenโ€™t done the next steps of the studies to evaluate that.โ€

Discussing public health officials and the pharmaceutical companies, Schaffner referenced Winston Churchillโ€™s quip about the United States and the United Kingdom being โ€œseparated by a common language.โ€

While some studies undoubtedly show that post-vaccination antibody levels decrease a bit over time, the result of that decrease isnโ€™t yet showing up in the epidemiological data. โ€œ[The CDC and FDA] are saying, โ€˜Look, weโ€™re measuring in the real world how long the protection is, and so far weโ€™re to about nine months to a yearโ€™s worth of protection, and furthermore, the protection seems to be really pretty good against all the variants that are circulating at the present time,โ€™โ€ Schaffner said. โ€œTheir criteria for needing the booster would be if actual protection begins to wane, then we begin to see people who are vaccinated now exposed and having to be hospitalized again, or that they can determine that there are variants circulating in the United States to which the vaccines are not providing protection. Neither of those criteria has been met.โ€

New COVID-19 cases and hospitalizations are surging again in Los Angeles, for example, but Dr. Christina Ghalyโ€”the countyโ€™s medical services directorโ€”said yesterday that not a single fully vaccinated person has been admitted to a county-operated hospital. Maryland public health officials presented similar data last week: Every person in the state who died from COVID-19 in June was unvaccinated.

Pfizer has yet to publicly release its three-dose clinical trial data, but that will likely change soon. The ACIP is scheduled to meet next Thursday, and Schaffner expects Pfizer to present its data then. Forman added that he hopes to see new Israeli seroprevalence dataโ€”the concentration of antibodies in blood serumโ€”soon as well.

More pressing than conversations about an eventual third dose, however, is getting first and second doses into the arms of the 30-plus percent of American adults who have thus far held off. From that perspective, any discussion of boosters is likely unhelpful. โ€œI think [public health officials] are worried that if you start a conversation around boosters now, it could discourage people who havenโ€™t been vaccinated from going out and seeking vaccination,โ€ former FDA commissioner (and Pfizer board member) Scott Gottlieb said on Face the Nation Sunday.

One move that could encourage more people to get the jab? The FDA issuing full approval for the COVID-19 vaccinesโ€”not just EUAs. Schaffner is impatient. โ€œThis is more information than the public hasโ€”and the FDA hasโ€”for any other vaccine ever licensed in FDA history,โ€ he said. Moving from EUAs to full approval would not only allow vaccine manufacturers to market their products directly to consumers, but it could prompt institutions that currently do not mandate the vaccineโ€”including the military and many medical centers, schools, universities, and businessesโ€”to add it to their list of required immunizations.

Dr. Anthony Fauci told CNBC yesterday that he would be โ€œastoundedโ€ if Pfizer, Moderna, and Johnson & Johnsonโ€™s vaccines did not receive full approval.ย 

Not So Transitory?

Itโ€™s starting to get a little repetitive. The Bureau of Labor Statistics (BLS) releases its latest Consumer Price Index (CPI) report about halfway through each month, and a day later we send you a TMD with headlines like โ€œPrices On the Riseโ€ and โ€œInflation Pains.โ€ Today, itโ€™s โ€œNot So Transitory?โ€

The CPI increased 0.9 percent from May to June according to this monthโ€™s BLS report, and 5.4 percent year-over-year. Both data points exceeded economistsโ€™ expectations yet again (0.5 percent and 4.9 percent, respectively), and both represent the fastest price growth in 13 yearsโ€”June 2008 for the former, August 2008 for the latter.

As weโ€™ve noted before, there are some caveats worth keeping in mind when looking at these eye-popping figures. Although the influence of the year-over-year base effect is beginning to waneโ€”most states had eased the harshest of lockdown restrictions by June 2020โ€”current prices are still being measured against a fairly low starting point. Remove that, and things donโ€™t look quite as dire. The CPI has risen 5.4 percent over the past year, but a much more manageableโ€”though still higher than normalโ€”3 percent averaged over the past two years.

The topline number is also less alarming if you remove a few key sectors that make up a disproportionate share of the growth. Semiconductor shortages and other pandemic-related supply chain hiccups are still affecting automobile manufacturing, and the resulting shortage is playing a significant role in the cost of used cars and trucks surging 45 percent year-over-year, and car and truck rentals nearly 88 percent. Used cars and trucks alone, per the BLS report, accounted for more than a third of Juneโ€™s overall increase.

Biden administration officials were quick to point this out Tuesday. Brian Deese, director of the White House National Economic Council (NEC), tweeted โ€œeye on the ballโ€ alongside a chart that excluded โ€œpandemic-affectedโ€ and โ€œvehicle-relatedโ€ items from core CPI inflation. โ€œFor most goods, inflation is 0.2%,โ€ added senior adviser Neera Tanden.

Norbert Michel, director of the Heritage Foundationโ€™s Center for Data Analysis, argued itโ€™s fair to slice and dice inflation data to a degreeโ€”but at some point doing so just becomes political spin. โ€œThere are valid reasons to pull out those items and focus on the core,โ€ he told The Dispatch. โ€œIf we say, โ€˜Well, weโ€™ll pull out car prices, if we pull out food, we pull out energy, those are all things that have been very severely impacted throughout the pandemic,โ€™ itโ€™s kind of like, โ€˜Well, yeah. Okay, that makes sense.โ€™โ€

โ€œBut if those problems donโ€™t get taken care of and get addressed, then itโ€™s not going to matter,โ€ Michel continued. โ€œAnd if itโ€™s the case that some of the policies that we have in place to deal with the pandemic that have caused those things arenโ€™t addressed and donโ€™t change, then youโ€™re just going to keep seeing things going up.โ€

Despite its public posturing, the Biden administration seems to be coming around to that realization. The New York Times reported yesterday that White House aides โ€œhave in recent weeks concluded that strong increases could linger for a year or more.โ€ Moreover, Obama administration NEC director Larry Summersโ€”who in March lambasted Bidenโ€™s American Rescue Plan as โ€œthe least responsible fiscal macroeconomic policy weโ€™ve have had for the last 40 yearsโ€โ€”was at the White House yesterday meeting with Deese and Council of Economic Advisers Chair Cecilia Rouse.

โ€œThese figures and labor market tightness and the behavior of housing markets and asset prices are all rising in a more concerning way than I worried about a few months ago,โ€ Summers told Politico on Tuesday. โ€œThis raises my degree of concern about an economic overheating scenario. There are huge uncertainties in the outlook, but I do believe the focus of concern right now should be on overheating.โ€

Summers isnโ€™t alone. An Echelon Insights survey conducted in mid-June found 71 percent of U.S. voters believe inflation is currently a โ€œvery bigโ€ or โ€œmoderately bigโ€ problem, and that number jumps to 79 percent if you replace โ€œinflationโ€ in the question prompt with โ€œrising prices.โ€ Sixty-five percent of respondents think increased government spending has contributed โ€œa great dealโ€ or โ€œa lotโ€ to the phenomenon.ย 

Senate Democrats last night unveiled a $3.5 trillion โ€œhuman infrastructureโ€ packageโ€”on top of the bipartisan $1.2 trillion โ€œinfrastructure infrastructureโ€ packageโ€”that they will try to pass through the budget reconciliation process. Sen. Joe Manchin did warn against additional deficit spending, however, saying Democrats โ€œneed to pay forโ€ the proposal to avoid accruing additional debt.

The institution with the most say over where inflation goes from hereโ€”the Federal Reserveโ€”will hold its monthly Federal Open Market Committee meeting in two weeks. In June, Chairman Jerome Powell said that it seemed like a few โ€œvery specific thingsโ€ were driving up inflation, and that the situation would be โ€œtemporary.โ€

Mary Daly, president of the San Francisco Federal Reserve, somewhat echoed this sentiment yesterday. โ€œWe expected a pop in inflation like this. โ€ฆ Demand came back faster than supply, and there are these temporary bottlenecks,โ€ she told CNBC. โ€œDonโ€™t read too much signal out of any month of data and letโ€™s get through this volatile period so we can really see where the economy is.โ€ย 

But Daly seemed to hint at future moves as well. โ€œIt is appropriate to start talking about tapering asset purchases, taking some of the accommodation that we have been providing to the economy down,โ€ she added. โ€œMy own view is weโ€™ll probably be in a good position to taper at the end of this year or early next.โ€

Worth Your Time

  • There is some justice in this world, because Apple TV+โ€™s hit series Ted Lasso secured 20 Emmy nominations yesterday. Not unrelatedly, GQ has published a delightful cover story profiling the showโ€™s star, Jason Sudeikis. Turns out, heโ€™s a lot like the character he plays on TV. โ€œThereโ€™s a great Michael J. Fox quote,โ€ Sudeikis told staff writer Zach Baron, trying to explain the particular brand of wary optimism that he carries around with him and that he ended up making a show about: โ€œโ€˜Donโ€™t assume the worst thingโ€™s going to happen, because on the off chance it does, youโ€™ll have lived through it twice.โ€™ So โ€ฆ why not do the inverse?โ€

  • Ramesh Ponnuru has a great piece in Bloomberg on President Bidenโ€™s speech Tuesday on voting rights in Philadelphia. โ€œBiden said that the voting system is threatened as it has not been since the Civil War. His recommended solution is to pass legislation that has been known for months to be dead in Congress and that wouldnโ€™t address the chief problem even if successful,โ€ he writes. โ€œBiden said that 17 states had passed 28 laws making it harder to vote. The same source behind those numbers also reports that 14 states have passed 28 laws making it easier to vote. Four states appear on both lists, which suggests that the legislation is more complicated than Bidenโ€™s talk of a โ€˜21st-century Jim Crow assaultโ€™ on voters would allow.โ€

Toeing the Company Line

  • Sarah and the gang continued their 2024 GOP primary preview Tuesday in The Sweep, digging into Ron DeSantis, Greg Abbott, and Kristi Noemโ€™s prospects. Plus, Chris Stirewalt drops by with some thoughts on corporate political donations and how transparency should work in an incredibly polarized time.

  • George Mason University economist Alex Tabarrok joined Jonah on The Remnant to discuss inflation, inoculations, and illiberalism. How can we revitalize democracy? Would open borders work? And should we abandon advanced civilization now before the machines destroy us all?

Let Us Know

If the COVID-19 vaccines do receive full FDA approval and public health officials begin recommending booster doses, would you have any problem getting a semi-regular COVID shot like you do with the flu, measles, tetanus, etc.?

Reporting by Declan Garvey (@declanpgarvey), Andrew Egger (@EggerDC), Charlotte Lawson (@charlotteUVA), Ryan Brown (@RyanP_Brown), Harvest Prude (@HarvestPrude), Tripp Grebe (@tripper_grebe), Emma Rogers (@emw_96), Price St. Clair (@PriceStClair1), Jonathan Chew (@JonathanChew19), and Steve Hayes (@stephenfhayes).

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